A lower incidence of Alzheimer's disease in smokers points to a compound called acetylcholine as the reason. Nicotine is structurally similar to acetylcholine a naturally-occurring compound that serves as a neurotransmitter.
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A libation is a ritual pouring of a liquid as an offering to a god or spirit or in memory of those who have died. It was common in many religions of antiquity and continues to be offered in various cultures today.
Sacred tobacco is used to make smoke clearing the space for offering as the prelude to communicating with the Spirit world
Pulque is an alcoholic beverage made from the fermented sap of the maguey [agave] plant. It is traditional to central Mexico where it has been produced for millennia.